View source for 8rpp


==Crystal structure of the JIP1-JIP2-SH3 heterodimer and the JIP2-JIP2-SH3 homodimer==
<StructureSection load='8rpp' size='340' side='right'caption='[[8rpp]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rpp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RPP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.867&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rpp OCA], [https://pdbe.org/8rpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rpp RCSB], [https://www.ebi.ac.uk/pdbsum/8rpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rpp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/JIP2_HUMAN JIP2_HUMAN] The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ielasi FI]]
[[Category: Jensen MR]]
[[Category: Marino-Perez L]]
[[Category: Palencia A]]