View source for 8rqk


==Structure of the complete Vaccinia DNA-dependent RNA polymerase complex at 2.65A resolution==
<StructureSection load='8rqk' size='340' side='right'caption='[[8rqk]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rqk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RQK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rqk OCA], [https://pdbe.org/8rqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rqk RCSB], [https://www.ebi.ac.uk/pdbsum/8rqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rqk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RP147_VACCC RP147_VACCC] Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates. Responsible for the transcription of early, intermediate and late genes. DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription. Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.[UniProtKB:O57204]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Bartuli J]]
[[Category: Fischer U]]
[[Category: Grimm C]]