View source for 8rqt


==Crystal structure of Pichia pastoris Pex8==
<StructureSection load='8rqt' size='340' side='right'caption='[[8rqt]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Komagataella_pastoris Komagataella pastoris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RQT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rqt OCA], [https://pdbe.org/8rqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rqt RCSB], [https://www.ebi.ac.uk/pdbsum/8rqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rqt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PEX8_PICPA PEX8_PICPA] Essential component of the machinery required for the import of both PTS1 and PTS2 (and perhaps all) peroxisomal matrix proteins (PubMed:7738036). Binding of PEX8 to the N-terminus of PEX5 cargo receptor induces a conformational change of the TPR domains and decrease their binding affinity to cargo, facilitating the release of the PTS1 proteins within the peroxisome (PubMed:23902771).<ref>PMID:23902771</ref> <ref>PMID:7738036</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Komagataella pastoris]]
[[Category: Large Structures]]
[[Category: Burgi J]]
[[Category: Chojnowski G]]
[[Category: Ekal L]]
[[Category: WIlmanns M]]