View source for 8rvp


==Proteasomal late precursor complex from pre1-1, state 2==
<StructureSection load='8rvp' size='340' side='right'caption='[[8rvp]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rvp]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RVP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rvp OCA], [https://pdbe.org/8rvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rvp RCSB], [https://www.ebi.ac.uk/pdbsum/8rvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rvp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSB6_YEAST PSB6_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Dohmen RJ]]
[[Category: Hoeckendorff J]]
[[Category: Kayser F]]
[[Category: Mark E]]
[[Category: Ramos PC]]
[[Category: Wendler P]]