View source for 8rxa


==ACDC domain of AP2-O5 from Plasmodium falciparum==
<StructureSection load='8rxa' size='340' side='right'caption='[[8rxa]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rxa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RXA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rxa OCA], [https://pdbe.org/8rxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rxa RCSB], [https://www.ebi.ac.uk/pdbsum/8rxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rxa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8IKY0_PLAF7 Q8IKY0_PLAF7] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Apicomplexan AP2 (ApiAP2) proteins are the best characterized family of DNA-binding proteins in the malaria parasite. Apart from the AP2 DNA-binding domain, there is little sequence similarity between ApiAP2 proteins and no other functional domains have been extensively characterized. One protein domain, which is present in a subset of the ApiAP2 proteins, is the conserved AP2-coincident domain mostly at the C-terminus (ACDC domain). Here we solved for the first time the crystal structure of the ACDC domain from two distinct Plasmodium falciparum ApiAP2 proteins and one orthologue from P. vivax , revealing a non-canonical four-helix bundle. Despite little sequence conservation between the ACDC domains from the two proteins, the structures are remarkably similar and do not resemble that of any other known protein domains. Due to their unique protein architecture and lack of homologues in the human genome, we performed in silico docking calculations against a library of known antimalarial compounds and we identified a small molecule that can potentially bind to any Apicomplexan ACDC domain within a pocket highly conserved amongst ApiAP2 proteins. Inhibitors based on this compound would disrupt the function of the ACDC domain and thus of the ApiAP2 proteins containing it, providing a new therapeutic window for targeting the malaria parasite and other Apicomplexans.

Structural characterization of the ACDC domain from ApiAP2 proteins of the malaria parasite.,Le Berre M, Tubiana T, Reutersward Waldner P, Lazar N, Li de la Sierra I, Santos JM, Llinas M, Nessler S bioRxiv [Preprint]. 2024 Feb 10:2024.02.09.579679. doi: , 10.1101/2024.02.09.579679. PMID:38370614<ref>PMID:38370614</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8rxa" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Gallay Li de la Sierra I]]
[[Category: Le Berre M]]
[[Category: Nessler S]]