View source for 8s62


==Cryo-EM structure of amprolium-bound human SLC19A3 in inward-open state==
<StructureSection load='8s62' size='340' side='right'caption='[[8s62]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8s62]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S62 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H5C:5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine'>A1H5C</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s62 OCA], [https://pdbe.org/8s62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s62 RCSB], [https://www.ebi.ac.uk/pdbsum/8s62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s62 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/S19A3_HUMAN S19A3_HUMAN] Thiamine-responsive encephalopathy;Biotin-thiamine-responsive basal ganglia disease;Infantile spasms-psychomotor retardation-progressive brain atrophy-basal ganglia disease syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/S19A3_HUMAN S19A3_HUMAN] Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed:11731220, PubMed:33008889, PubMed:35512554, PubMed:35724964). Has no folate transport activity (PubMed:11731220). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964, PubMed:36456177).<ref>PMID:11731220</ref> <ref>PMID:33008889</ref> <ref>PMID:35512554</ref> <ref>PMID:35724964</ref> <ref>PMID:36456177</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Gabriel F]]
[[Category: Loew C]]