View source for 8shj


==Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279==
<StructureSection load='8shj' size='340' side='right'caption='[[8shj]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8shj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SHJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZI8:N-[3-(4-chlorophenyl)oxetan-3-yl]-4-[(3S)-3-hydroxypyrrolidin-1-yl]benzamide'>ZI8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8shj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8shj OCA], [https://pdbe.org/8shj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8shj RCSB], [https://www.ebi.ac.uk/pdbsum/8shj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8shj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ackloo S]]
[[Category: Ahmad H]]
[[Category: Arrowsmith CH]]
[[Category: Brown PJ]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Feng JW]]
[[Category: Halabelian L]]
[[Category: Hutchinson A]]
[[Category: Li Y]]
[[Category: Seitova A]]
[[Category: Xu J]]
[[Category: Zeng H]]