View source for 8sny


==Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the trailer complementary promoter==
<StructureSection load='8sny' size='340' side='right'caption='[[8sny]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8sny]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Respiratory_syncytial_virus_A2 Respiratory syncytial virus A2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SNY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sny OCA], [https://pdbe.org/8sny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sny RCSB], [https://www.ebi.ac.uk/pdbsum/8sny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sny ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/L_HRSVA L_HRSVA] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).<ref>PMID:8445369</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Respiratory syncytial virus A2]]
[[Category: Cao D]]
[[Category: Chen Z]]
[[Category: Gao Y]]
[[Category: Gooneratne I]]
[[Category: Liang B]]
[[Category: Mera C]]
[[Category: Roesler C]]