View source for 8st6


==Hsa Siglec + Unique domains bound to Neu5Gc alpha2,3 Gal beta OMe==
<StructureSection load='8st6' size='340' side='right'caption='[[8st6]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8st6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_gordonii_str._Challis_substr._CH1 Streptococcus gordonii str. Challis substr. CH1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ST6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ST6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=USR:methyl+3-O-[3,5-dideoxy-5-(2-hydroxyacetamido)-L-glycero-alpha-D-gulo-non-2-ulopyranonosyl]-beta-D-talopyranoside'>USR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8st6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8st6 OCA], [https://pdbe.org/8st6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8st6 RCSB], [https://www.ebi.ac.uk/pdbsum/8st6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8st6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HSA_STRGC HSA_STRGC] A cell wall protein involved with PadA in host cell interactions required for colonization and pathogensis (Probable) (PubMed:19884334, PubMed:27616700). Mediates hemagglutination and adherence to ghst glycoproteins (PubMed:11854202). Recognizes fetuin-A (AHSG), a highly glycosylated human plasma protein, also involved in recognition of human platelets, probably via platelet glycoprotein Ib alpha (GP1BA) (PubMed:19884334). Acts in concert with PadA to promote binding to glycosylated human fibronectin (FN1) and vitronectin (VTN), and biofilm formation. Plays a major role in fibronectin and vitronectin binding; binding is mediated by glycosylated regions. Probably mediates interaction of PadA with resting platelets (PubMed:27616700).<ref>PMID:11854202</ref> <ref>PMID:19884334</ref> <ref>PMID:27616700</ref> <ref>PMID:11854202</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus gordonii str. Challis substr. CH1]]
[[Category: Iverson TM]]
[[Category: Stubbs HE]]