View source for 8ta4


==Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal==
<StructureSection load='8ta4' size='340' side='right'caption='[[8ta4]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ta4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TA4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ta4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ta4 OCA], [https://pdbe.org/8ta4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ta4 RCSB], [https://www.ebi.ac.uk/pdbsum/8ta4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ta4 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CLCN2_HUMAN CLCN2_HUMAN] Leukoencephalopathy with mild cerebellar ataxia and white matter edema;Familial hyperaldosteronism type II;Juvenile myoclonic epilepsy. Disease susceptibility is associated with variants affecting the gene represented in this entry.  Disease susceptibility may be associated with variants affecting the gene represented in this entry.  Disease susceptibility is associated with variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CLCN2_HUMAN CLCN2_HUMAN] Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012).<ref>PMID:19153159</ref> <ref>PMID:19191339</ref> <ref>PMID:29403011</ref> <ref>PMID:29403012</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chiu W]]
[[Category: Dror RO]]
[[Category: Du Bois J]]
[[Category: Liu Y]]
[[Category: Maduke M]]
[[Category: Miller S]]
[[Category: Neelands T]]
[[Category: Pintilie G]]
[[Category: Powers AS]]
[[Category: Xu M]]