View source for 8tau


==APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB==
<StructureSection load='8tau' size='340' side='right'caption='[[8tau]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tau]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TAU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tau OCA], [https://pdbe.org/8tau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tau RCSB], [https://www.ebi.ac.uk/pdbsum/8tau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tau ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/APC1_HUMAN APC1_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Amann SJ]]
[[Category: Bodrug T]]
[[Category: Bolhuis DL]]
[[Category: Bonacci T]]
[[Category: Brown NG]]
[[Category: Cui L]]
[[Category: Emanuele MJ]]
[[Category: Grishkovskaya I]]
[[Category: Hahn KM]]
[[Category: Harrison JS]]
[[Category: Haselbach D]]
[[Category: Liu B]]
[[Category: Martinez-Chacin RC]]
[[Category: Paulakonis E]]
[[Category: Pinkin N]]
[[Category: Roscow O]]
[[Category: Steimel JP]]
[[Category: Welsh KA]]
[[Category: Xu P]]
[[Category: Zhang W]]
[[Category: Zhong E]]