View source for 8tce


==Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3353871==
<StructureSection load='8tce' size='340' side='right'caption='[[8tce]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tce]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TCE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HWF:(2S)-3-phenyl-2-[(3R)-pyrrolidin-3-yl]propanoic+acid'>HWF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tce OCA], [https://pdbe.org/8tce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tce RCSB], [https://www.ebi.ac.uk/pdbsum/8tce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tce ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hendle J]]
[[Category: Sauder JM]]
[[Category: Weichert K]]