View source for 8tga


==Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound==
<StructureSection load='8tga' size='340' side='right'caption='[[8tga]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tga]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TGA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.65&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tga OCA], [https://pdbe.org/8tga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tga RCSB], [https://www.ebi.ac.uk/pdbsum/8tga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tga ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANPRA_HUMAN ANPRA_HUMAN] Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.<ref>PMID:1672777</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Franklin MC]]
[[Category: Romero Hernandez A]]