View source for 8tgh


==VMAT1 dimer with amphetamine and reserpine==
<StructureSection load='8tgh' size='340' side='right'caption='[[8tgh]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TGH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WE:(2S)-1-PHENYLPROPAN-2-AMINE'>1WE</scene>, <scene name='pdbligand=YHR:reserpine'>YHR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tgh OCA], [https://pdbe.org/8tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tgh RCSB], [https://www.ebi.ac.uk/pdbsum/8tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tgh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VMAT1_HUMAN VMAT1_HUMAN] Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:23337945, PubMed:8643547, PubMed:16326835). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (PubMed:23337945).<ref>PMID:16326835</ref> <ref>PMID:23337945</ref> <ref>PMID:8643547</ref>   Unable to uptake serotonin.<ref>PMID:16326835</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li W]]
[[Category: Liu B]]
[[Category: Ye J]]