View source for 8thi


==Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (parallel dimer)==
<StructureSection load='8thi' size='340' side='right'caption='[[8thi]], [[Resolution|resolution]] 3.36&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8thi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8THI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8THI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.36&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8thi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8thi OCA], [https://pdbe.org/8thi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8thi RCSB], [https://www.ebi.ac.uk/pdbsum/8thi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8thi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIAT1_HAEIN SIAT1_HAEIN] Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid (N-acetyl-beta-neuraminate). N-Acetylneuraminate can then be incorporated into the lipopolysaccharides as a terminal non-reducing sugar, protecting the bacterium from complement-mediated killing by normal human serum.<ref>PMID:16262798</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Haemophilus influenzae Rd KW20]]
[[Category: Large Structures]]
[[Category: Currie MC]]
[[Category: Davies JS]]
[[Category: Dobson RCJ]]
[[Category: North RA]]