View source for 8tl1


==Structure of Orthoreovirus RNA Chaperone SigmaNS N17==
<StructureSection load='8tl1' size='340' side='right'caption='[[8tl1]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tl1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthoreovirus Orthoreovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TL1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCH:GLYCOCHOLIC+ACID'>GCH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tl1 OCA], [https://pdbe.org/8tl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tl1 RCSB], [https://www.ebi.ac.uk/pdbsum/8tl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tl1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIGNS_REOVD SIGNS_REOVD] Protein that binds to ssRNA and participates with protein mu-NS in forming the matrix of viral factories, which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place (PubMed:11152519). Plays a role in the inhibition of the integrated stress response (ISR) to escape from host cell translational shutoff (PubMed:28794026). Participates in the disruption of stress granules (SG) through its association with host G3BP1 and mu-NS (PubMed:28794026).<ref>PMID:11152519</ref> <ref>PMID:28794026</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Orthoreovirus]]
[[Category: Hu L]]
[[Category: Prasad BVV]]
[[Category: Zhao B]]