View source for 8tmw


==HTLV-1 capsid protein N-terminal domain triclinic crystal form with sulphate ion==
<StructureSection load='8tmw' size='340' side='right'caption='[[8tmw]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tmw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/HTLV-1_subtype_C HTLV-1 subtype C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TMW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tmw OCA], [https://pdbe.org/8tmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tmw RCSB], [https://www.ebi.ac.uk/pdbsum/8tmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tmw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/U3RC00_9DELA U3RC00_9DELA] Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.[ARBA:ARBA00002374]  Forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.[ARBA:ARBA00037500]  Matrix protein.[ARBA:ARBA00003230]  The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.[ARBA:ARBA00037194]
__TOC__
</StructureSection>
[[Category: HTLV-1 subtype C]]
[[Category: Large Structures]]
[[Category: Jacques DA]]
[[Category: Li N]]
[[Category: Yu RJ]]