View source for 8tr5


==Cryo-EM structure of the rat P2X7 receptor in the apo closed state==
<StructureSection load='8tr5' size='340' side='right'caption='[[8tr5]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tr5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus Rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TR5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tr5 OCA], [https://pdbe.org/8tr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tr5 RCSB], [https://www.ebi.ac.uk/pdbsum/8tr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tr5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P2RX7_RAT P2RX7_RAT] Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus]]
[[Category: Glasfeld A]]
[[Category: Godsey MH]]
[[Category: Krishnamurthy I]]
[[Category: Lisi NE]]
[[Category: Mansoor SE]]
[[Category: McCarthy AE]]
[[Category: Oken AC]]