View source for 8tuf


==Crystal structure of human norovirus RNA-dependent RNA-polymerase==
<StructureSection load='8tuf' size='340' side='right'caption='[[8tuf]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tuf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.4/Sydney/NSW0514/2012/AU Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TUF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tuf OCA], [https://pdbe.org/8tuf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tuf RCSB], [https://www.ebi.ac.uk/pdbsum/8tuf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tuf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/K4L8Z7_9CALI K4L8Z7_9CALI] 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.[PROSITE-ProRule:PRU00870]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Norovirus Hu/GII 4/Sydney/NSW0514/2012/AU]]
[[Category: Kaundal S]]
[[Category: Prasad BVV]]
[[Category: Sankaran B]]