View source for 8tvf


==Langya henipavirus fusion protein in prefusion state==
<StructureSection load='8tvf' size='340' side='right'caption='[[8tvf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tvf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Langya_virus Langya virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TVF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tvf OCA], [https://pdbe.org/8tvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tvf RCSB], [https://www.ebi.ac.uk/pdbsum/8tvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tvf ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Langya virus (LayV) is a recently discovered henipavirus (HNV), isolated from febrile patients in China. HNV entry into host cells is mediated by the attachment (G) and fusion (F) glycoproteins which are the main targets of neutralizing antibodies. We show here that the LayV F and G glycoproteins promote membrane fusion with human, mouse, and hamster target cells using a different, yet unknown, receptor than Nipah virus (NiV) and Hendra virus (HeV) and that NiV- and HeV-elicited monoclonal and polyclonal antibodies do not cross-react with LayV F and G. We determined cryoelectron microscopy structures of LayV F, in the prefusion and postfusion states, and of LayV G, revealing their conformational landscape and distinct antigenicity relative to NiV and HeV. We computationally designed stabilized LayV G constructs and demonstrate the generalizability of an HNV F prefusion-stabilization strategy. Our data will support the development of vaccines and therapeutics against LayV and closely related HNVs.

Structure and design of Langya virus glycoprotein antigens.,Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2314990121. doi: , 10.1073/pnas.2314990121. Epub 2024 Apr 9. PMID:38593070<ref>PMID:38593070</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Langya virus]]
[[Category: Large Structures]]
[[Category: Veesler D]]
[[Category: Wang Z]]