View source for 8tvi


==Langya Virus G glycoprotein (LayV G) with stabilizing mutations==
<StructureSection load='8tvi' size='340' side='right'caption='[[8tvi]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tvi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Langya_virus Langya virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TVI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tvi OCA], [https://pdbe.org/8tvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tvi RCSB], [https://www.ebi.ac.uk/pdbsum/8tvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tvi ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Langya virus (LayV) is a recently discovered henipavirus (HNV), isolated from febrile patients in China. HNV entry into host cells is mediated by the attachment (G) and fusion (F) glycoproteins which are the main targets of neutralizing antibodies. We show here that the LayV F and G glycoproteins promote membrane fusion with human, mouse, and hamster target cells using a different, yet unknown, receptor than Nipah virus (NiV) and Hendra virus (HeV) and that NiV- and HeV-elicited monoclonal and polyclonal antibodies do not cross-react with LayV F and G. We determined cryoelectron microscopy structures of LayV F, in the prefusion and postfusion states, and of LayV G, revealing their conformational landscape and distinct antigenicity relative to NiV and HeV. We computationally designed stabilized LayV G constructs and demonstrate the generalizability of an HNV F prefusion-stabilization strategy. Our data will support the development of vaccines and therapeutics against LayV and closely related HNVs.

Structure and design of Langya virus glycoprotein antigens.,Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2314990121. doi: , 10.1073/pnas.2314990121. Epub 2024 Apr 9. PMID:38593070<ref>PMID:38593070</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Langya virus]]
[[Category: Large Structures]]
[[Category: McCallum M]]
[[Category: Veesler D]]