View source for 8txu


==Fab 3864-10 in complex with influenza HA H3-SING16==
<StructureSection load='8txu' size='340' side='right'caption='[[8txu]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8txu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TXU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8txu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8txu OCA], [https://pdbe.org/8txu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8txu RCSB], [https://www.ebi.ac.uk/pdbsum/8txu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8txu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A5B8WNB2_9INFA A0A5B8WNB2_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
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</StructureSection>
[[Category: Influenza A virus]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Morano NC]]
[[Category: Shapiro L]]