View source for 8u91


==Crystal structure of N-acetylneuraminate lyase (NanA) from Klebsiella aerogenes (Apo, Orthorhombic P form)==
<StructureSection load='8u91' size='340' side='right'caption='[[8u91]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8u91]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_aerogenes_KCTC_2190 Klebsiella aerogenes KCTC 2190]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U91 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u91 OCA], [https://pdbe.org/8u91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u91 RCSB], [https://www.ebi.ac.uk/pdbsum/8u91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u91 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0H3FJT8_KLEAK A0A0H3FJT8_KLEAK] Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.[HAMAP-Rule:MF_01237]
__TOC__
</StructureSection>
[[Category: Klebsiella aerogenes KCTC 2190]]
[[Category: Large Structures]]