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==Crystal structure of hetero hexameric hazelnut allergen Cor a 9==
<StructureSection load='8uai' size='340' side='right'caption='[[8uai]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8uai]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Corylus_avellana Corylus avellana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UAI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uai OCA], [https://pdbe.org/8uai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uai RCSB], [https://www.ebi.ac.uk/pdbsum/8uai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uai ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8W1C2_CORAV Q8W1C2_CORAV] Seed storage protein.[ARBA:ARBA00003839][RuleBase:RU003681]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Edible plant seeds provide a relatively inexpensive source of protein and make up a large part of nutrients for humans. Plant seeds accumulate storage proteins during seed development. Seed storage proteins act as a reserve of nutrition for seed germination and seedling growth. However, seed storage proteins may be allergenic, and the prevalence of food allergy has increased rapidly in recent years. The 11S globulins account for a significant number of known major food allergens. They are of interest to the public and the agricultural industry because of food safety concerns and the need for crop enhancement. We sought to determine the crystal structure of Cor a 9, the 11 S storage protein of hazelnut and a food allergen. The structure was refined to 1.92 A, and the R and R(free) for the refined structure are 17.6% and 22.5%, respectively. The structure of Cor a 9 showed a hetero hexamer of an 11S seed storage protein for the first time. The hexamer was two trimers associated back-to-back. Two long alpha helixes at the C-terminal end of the acidic domain of one of the Cor a 9 isoforms lay at the trimer-trimer interface's groove. These data provided much-needed information about the allergenicity of the 11S seed proteins. The information may also facilitate a better understanding of the folding and transportation of 11S seed storage proteins.

Crystal structure of hetero hexameric 11S seed storage protein of hazelnut.,Guo F, Zhang Y, Howard A, Xu Y Plant Physiol Biochem. 2024 May;210:108653. doi: 10.1016/j.plaphy.2024.108653. , Epub 2024 Apr 20. PMID:38670029<ref>PMID:38670029</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8uai" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Corylus avellana]]
[[Category: Large Structures]]
[[Category: Guo F]]
[[Category: Zhang YZ]]