View source for 8uav


==Cryo-EM Structure of Brucella Abortus Lumazine Synthase (BLS) Engineered with Shiga Toxin I subunit B (Stx1B)==
<StructureSection load='8uav' size='340' side='right'caption='[[8uav]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8uav]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus_bv._1_str._9-941 Brucella abortus bv. 1 str. 9-941] and [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UAV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uav OCA], [https://pdbe.org/8uav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uav RCSB], [https://www.ebi.ac.uk/pdbsum/8uav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uav ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7DH26_ECO57 Q7DH26_ECO57] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.[ARBA:ARBA00003218][https://www.uniprot.org/uniprot/RISB2_BRUAB RISB2_BRUAB] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. Displays low catalytic activity in comparison with the isozyme RibH1.<ref>PMID:10482294</ref> <ref>PMID:16165152</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Brucella abortus bv. 1 str. 9-941]]
[[Category: Escherichia coli O157:H7]]
[[Category: Large Structures]]
[[Category: Borgnia MJ]]
[[Category: Cerutti ML]]
[[Category: Cristofalo AE]]
[[Category: Goldbaum FA]]
[[Category: Otero LH]]
[[Category: Sharma A]]
[[Category: Sharma K]]
[[Category: Zylberman V]]