View source for 8ucx


==Dihydrofolate Reductase Complexed with Folate==
<StructureSection load='8ucx' size='340' side='right'caption='[[8ucx]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ucx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UCX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ucx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ucx OCA], [https://pdbe.org/8ucx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ucx RCSB], [https://www.ebi.ac.uk/pdbsum/8ucx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ucx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C3TR70_ECOLX C3TR70_ECOLX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Boxer SG]]
[[Category: Fried SDE]]