View source for 8ufo


==Crystal Structure of Gastrointestinal HAstV VA1 capsid spike domain at 1.46 A resolution==
<StructureSection load='8ufo' size='340' side='right'caption='[[8ufo]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ufo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Astrovirus_VA1 Astrovirus VA1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UFO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ufo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ufo OCA], [https://pdbe.org/8ufo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ufo RCSB], [https://www.ebi.ac.uk/pdbsum/8ufo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ufo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C7BG48_9VIRU C7BG48_9VIRU] The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis.[RuleBase:RU363102]
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</StructureSection>
[[Category: Astrovirus VA1]]
[[Category: Large Structures]]
[[Category: DuBois RM]]
[[Category: Ghosh A]]