View source for 8ugw


==Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks==
<StructureSection load='8ugw' size='340' side='right'caption='[[8ugw]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ugw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UGW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NGI:2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5-N-ETHYLCARBOXAMIDO+ADENOSINE'>NGI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ugw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ugw OCA], [https://pdbe.org/8ugw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ugw RCSB], [https://www.ebi.ac.uk/pdbsum/8ugw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ugw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia virus T4]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Baker K]]
[[Category: Barth P]]
[[Category: Benach J]]
[[Category: Chau B]]
[[Category: Chen KY]]
[[Category: Condon B]]
[[Category: Conners K]]
[[Category: Hembre EJ]]
[[Category: Kodandapani L]]
[[Category: Lai JK]]
[[Category: Russell AM]]
[[Category: Rutter ME]]
[[Category: Tung F]]
[[Category: Wang J]]
[[Category: Zhao X]]