View source for 8usp


==Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway==
<StructureSection load='8usp' size='340' side='right'caption='[[8usp]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8usp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces Saccharomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8USP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8USP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8usp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8usp OCA], [https://pdbe.org/8usp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8usp RCSB], [https://www.ebi.ac.uk/pdbsum/8usp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8usp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MET18_YEAST MET18_YEAST] Key component of the cytosolic iron-sulfur protein assembly (CIA) machinery that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. Acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as RAD3/XPD and DNA2, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription.<ref>PMID:18836076</ref> <ref>PMID:22678362</ref> <ref>PMID:392238</ref> <ref>PMID:8943333</ref> <ref>PMID:9321645</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces]]
[[Category: Drennan CL]]
[[Category: Vasquez S]]