View source for 8uxq


==Structure of Heterochromatin Protein 1 (HP1) alpha in complex with an H2A.Z nucleosome==
<StructureSection load='8uxq' size='340' side='right'caption='[[8uxq]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8uxq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UXQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uxq OCA], [https://pdbe.org/8uxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uxq RCSB], [https://www.ebi.ac.uk/pdbsum/8uxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uxq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CBX5_HUMAN CBX5_HUMAN] Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.<ref>PMID:19783980</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Xenopus laevis]]
[[Category: Sokolova V]]
[[Category: Tan D]]