View source for 8uxs


==KLHDC2 ubiquitin ligase in complex with a novel small-molecule==
<StructureSection load='8uxs' size='340' side='right'caption='[[8uxs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8uxs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UXS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XU8:{4-[(2-{[(4-tert-butylphenyl)methyl]sulfanyl}acetamido)methyl]-1H-1,2,3-triazol-1-yl}acetic+acid'>XU8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uxs OCA], [https://pdbe.org/8uxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uxs RCSB], [https://www.ebi.ac.uk/pdbsum/8uxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uxs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KLDC2_HUMAN KLDC2_HUMAN] Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.<ref>PMID:11384994</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rusnac DV]]
[[Category: Zheng N]]