View source for 8uy5


==[ZP] Self-assembling DNA crystal with expanded genetic code using C,A,T,G, Z and P nucleotides==
<StructureSection load='8uy5' size='340' side='right'caption='[[8uy5]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8uy5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UY5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.562&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DP:DISOPYRAMIDE'>DP</scene>, <scene name='pdbligand=DZ:N-(3,5-DIBROMO-4-HYDROXYPHENYL)-2,6-DIMETHYLBENZAMIDE'>DZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uy5 OCA], [https://pdbe.org/8uy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uy5 RCSB], [https://www.ebi.ac.uk/pdbsum/8uy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uy5 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Artificially expanded genetic information systems (AEGIS) were developed to expand the diversity and functionality of biological systems. Recent experiments have shown that these expanded DNA molecular systems are robust platforms for information storage and retrieval as well as useful for basic biotechnologies. In tandem, nucleic acid nanotechnology has seen the use of information-based "semantomorphic" encoding to drive the self-assembly of a vast array of supramolecular devices. To establish the effectiveness of AEGIS toward nanotechnological applications, we investigated the ability of a six-letter alphabet composed of A:T, G:C and synthetic Z:P (Z, 6-amino-3-(1'-beta-d-2'-deoxy ribofuranosyl)-5-nitro-(1H)-pyridin-2-one; P, 2-amino-8-(1'-beta-d-2'-deoxyribofuranosyl)-imidazo-[1,2a]-1,3,5-triazin-(8H)-4-one) base pairs to engage in 3D self-assembly. We found that crystals could be programmably assembled from AEGIS oligomers. We conclude that unnatural base pairs can be used for the topological self-assembly of crystals. We anticipate the expansion of AEGIS-based nucleic acid nanotechnologies to enable the development of novel nanomaterials, high-fidelity signal cascades, and dynamic nanoscale devices.

Six-Letter DNA Nanotechnology: Incorporation of Z-P Base Pairs into Self-Assembling 3D Crystals.,Vecchioni S, Ohayon YP, Hernandez C, Hoshika S, Mao C, Benner SA, Sha R Nano Lett. 2024 Nov 13;24(45):14302-14306. doi: 10.1021/acs.nanolett.4c03949. , Epub 2024 Oct 29. PMID:39471314<ref>PMID:39471314</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 8uy5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Hernandez C]]
[[Category: Ohayon YP]]
[[Category: Sha R]]
[[Category: Vecchioni S]]