View source for 8v0j


==Structure of the complex between Human LIAS and H-protein in the presence of s-adenosyl-l-methionine==
<StructureSection load='8v0j' size='340' side='right'caption='[[8v0j]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8v0j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V0J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=YVI:(6~{S})-6-sulfanyloctanoic+acid'>YVI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v0j OCA], [https://pdbe.org/8v0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v0j RCSB], [https://www.ebi.ac.uk/pdbsum/8v0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v0j ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/LIAS_HUMAN LIAS_HUMAN] Lipoic acid synthetase deficiency. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/LIAS_HUMAN LIAS_HUMAN] Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.[HAMAP-Rule:MF_03123]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alumasa JN]]
[[Category: Booker SJ]]
[[Category: Esakova OA]]
[[Category: Neti SS]]
[[Category: Warui DM]]