View source for 8v5u


==Human SIRT3 bound to p53-AMC peptide and Honokiol==
<StructureSection load='8v5u' size='340' side='right'caption='[[8v5u]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8v5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V5U FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=MCM:7-AMINO-4-METHYL-CHROMEN-2-ONE'>MCM</scene>, <scene name='pdbligand=Y4T:(1P)-3,5-di(prop-2-en-1-yl)[1,1-biphenyl]-2,4-diol'>Y4T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v5u OCA], [https://pdbe.org/8v5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v5u RCSB], [https://www.ebi.ac.uk/pdbsum/8v5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v5u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chakrabarti R]]
[[Category: Chall S]]
[[Category: Delacroix T]]
[[Category: Dumpati RK]]
[[Category: Errasti G]]
[[Category: Ghosh A]]
[[Category: Guan X]]
[[Category: Munshi S]]
[[Category: Rahnamoun A]]
[[Category: Reverdy C]]
[[Category: Roy S]]
[[Category: Upadhyay A]]