View source for 8v76


==Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 12==
<StructureSection load='8v76' size='340' side='right'caption='[[8v76]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8v76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V76 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YIU:~{N}-[3-[5-(2~{H}-1,2,3,4-tetrazol-5-yl)-2,1-benzoxazol-3-yl]phenyl]cyclopentanecarboxamide'>YIU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v76 OCA], [https://pdbe.org/8v76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v76 RCSB], [https://www.ebi.ac.uk/pdbsum/8v76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v76 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IPMK_HUMAN IPMK_HUMAN] Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).<ref>PMID:12027805</ref> <ref>PMID:12223481</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Shears SB]]
[[Category: Wang H]]