View source for 8vie


==2-PPA bound human TMEM175==
<StructureSection load='8vie' size='340' side='right'caption='[[8vie]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8vie]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VIE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.52&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vie OCA], [https://pdbe.org/8vie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vie RCSB], [https://www.ebi.ac.uk/pdbsum/8vie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vie ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. TMEM175 defects result in unstable lysosomal pH, leading to decreased lysosomal catalytic activity, decreased glucocerebrosidase activity, impaired autophagosome clearance by the lysosome and decreased mitochondrial respiration (PubMed:28193887).<ref>PMID:28193887</ref> 
== Function ==
[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.<ref>PMID:26317472</ref> <ref>PMID:28723891</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hite RK]]
[[Category: Oh S]]