View source for 8vis


==Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide==
<StructureSection load='8vis' size='340' side='right'caption='[[8vis]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8vis]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VIS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vis OCA], [https://pdbe.org/8vis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vis RCSB], [https://www.ebi.ac.uk/pdbsum/8vis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vis ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TM11D_HUMAN TM11D_HUMAN] May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.<ref>PMID:23536651</ref> <ref>PMID:24227843</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Benard F]]
[[Category: Dong A]]
[[Category: Edwards A]]
[[Category: Fraser BJ]]
[[Category: Hejazi Z]]
[[Category: Ilyassov O]]
[[Category: Kenney T]]
[[Category: Li Y]]
[[Category: Li YY]]
[[Category: Seitova A]]