View source for 8vsd


==avb8/L-TGF-b1/GARP==
<StructureSection load='8vsd' size='340' side='right'caption='[[8vsd]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8vsd]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VSD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vsd OCA], [https://pdbe.org/8vsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vsd RCSB], [https://www.ebi.ac.uk/pdbsum/8vsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vsd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LRC32_HUMAN LRC32_HUMAN] Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).[UniProtKB:G3XA59]<ref>PMID:19651619</ref> <ref>PMID:19750484</ref> <ref>PMID:22278742</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng Y]]
[[Category: Jin M]]
[[Category: Nishimura SL]]