View source for 8vsl


==Binary structure of 14-3-3 sigma and ARAF phosphopeptide (pS214)==
<StructureSection load='8vsl' size='340' side='right'caption='[[8vsl]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8vsl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VSL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vsl OCA], [https://pdbe.org/8vsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vsl RCSB], [https://www.ebi.ac.uk/pdbsum/8vsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vsl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arkin MR]]
[[Category: Brunsveld L]]
[[Category: Konstantinidou M]]
[[Category: Neitz RJ]]
[[Category: Ottmann C]]
[[Category: Pennings M]]
[[Category: Vickery HR]]
[[Category: Virta JM]]
[[Category: Van den Oetelaar M]]