View source for 8vvc


==Cryo-EM structure of human ABC transporter (hABCC1) with nucleotide-binding domain 2==
<StructureSection load='8vvc' size='340' side='right'caption='[[8vvc]], [[Resolution|resolution]] 4.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8vvc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VVC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.32&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vvc OCA], [https://pdbe.org/8vvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vvc RCSB], [https://www.ebi.ac.uk/pdbsum/8vvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vvc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MRP1_HUMAN MRP1_HUMAN] Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.<ref>PMID:10064732</ref> <ref>PMID:11114332</ref> <ref>PMID:16230346</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li P]]
[[Category: Shinde O]]