View source for 8w6d


==CryoEM structure of NaDC1 in apo state==
<StructureSection load='8w6d' size='340' side='right'caption='[[8w6d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8w6d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W6D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PH:1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE'>3PH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w6d OCA], [https://pdbe.org/8w6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w6d RCSB], [https://www.ebi.ac.uk/pdbsum/8w6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w6d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S13A2_HUMAN S13A2_HUMAN] Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:9668069, PubMed:8967342). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:8967342, PubMed:9668069, PubMed:10894787). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity).[UniProtKB:Q9ES88]<ref>PMID:10894787</ref> <ref>PMID:8967342</ref> <ref>PMID:9668069</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen Y]]
[[Category: Chi X]]
[[Category: Li Y]]
[[Category: Shen Y]]
[[Category: Wang Z]]
[[Category: Yan R]]
[[Category: Zhang Y]]