View source for 8wd5


==Crystal structure of farnesyl diphosphate synthase FPPS1 from silkworm, Bombyx mori==
<StructureSection load='8wd5' size='340' side='right'caption='[[8wd5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wd5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WD5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wd5 OCA], [https://pdbe.org/8wd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wd5 RCSB], [https://www.ebi.ac.uk/pdbsum/8wd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wd5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q95P28_BOMMO Q95P28_BOMMO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Farnesyl diphosphate synthase (FPPS) is an important enzyme involved in the juvenile hormone (JH) biosynthesis pathway. Herein, we report the crystal structure of a type-I Lepidopteran FPPS from Bombyx mori (BmFPPS1) at 2.80 A resolution. BmFPPS1 adopts an alpha-helix structure with a deep cavity at the center of the overall structure. Computational simulations combined with biochemical analysis allowed us to define the binding mode of BmFPPS1 to its substrates. Structural comparison revealed that BmFPPS1 adopts a structural pattern similar to that of type-II FPPS but exhibits a distinct substrate-binding site. These findings provide a structural basis for understanding substrate preferences and designing FPPS inhibitors. Furthermore, the expression profiles and RNA interference of BmFPPSs indicated that they play critical roles in the JH biosynthesis and larval-pupal metamorphosis. These findings enhance our understanding of the structural features of type-I Lepidopteran FPPS while providing direct evidence for the physiological role of BmFPPSs in silkworm development.

Structural Insights into the Substrate Binding of Farnesyl Diphosphate Synthase FPPS1 from Silkworm, Bombyx mori.,Fang H, Zheng H, Yang Y, Hu Y, Wang Z, Xia Q, Guo P J Agric Food Chem. 2024 Jan 24;72(3):1787-1796. doi: 10.1021/acs.jafc.3c06741. , Epub 2024 Jan 12. PMID:38214248<ref>PMID:38214248</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8wd5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Bombyx mori]]
[[Category: Large Structures]]
[[Category: Fang H]]
[[Category: Guo PC]]