View source for 8wdq


==Crystal Structure of Pseudomonas aeruginosa SuhB in complex with D-myo-inositol-1-phosphate==
<StructureSection load='8wdq' size='340' side='right'caption='[[8wdq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wdq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WDQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPD:D-MYO-INOSITOL-1-PHOSPHATE'>IPD</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wdq OCA], [https://pdbe.org/8wdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wdq RCSB], [https://www.ebi.ac.uk/pdbsum/8wdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wdq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SUHB_PSEAE SUHB_PSEAE] Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. This subunit may play a central role in organizing the structure.[UniProtKB:P0ADG4]  A ribosome-associated protein, deletion of which alters the expression of 494 genes, suggesting a role in global gene regulation (PubMed:26179141). Involved in control of pathogenesis-related genes. Required for the activation of virulence factors associated with acute infections (type 3 secretion system, T3SS) while suppressing virulence factors associated with chronic infections (biofilm formation and type 6 secretion system, T6SS). It probably acts at a post-transcriptional level (PubMed:24169572).<ref>PMID:24169572</ref> <ref>PMID:26179141</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Bhattacharyya S]]
[[Category: Maji S]]
[[Category: Shukla M]]
[[Category: Yadav VK]]