View source for 8wec


==Crystal structure of Arabidopsis thaliana MIK2 ectodomain in complex with BAK1 ectodomain and SCOOP12==
<StructureSection load='8wec' size='340' side='right'caption='[[8wec]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wec]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WEC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wec OCA], [https://pdbe.org/8wec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wec RCSB], [https://www.ebi.ac.uk/pdbsum/8wec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wec ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MIK2_ARATH MIK2_ARATH] Acts as a receptor of SCOOP peptides from Brassicaceae plants regulating multiple processing including plant growth, development and stress responses (PubMed:33514716, PubMed:34535661). Perception of SCOOP peptides induces the association of MIK2 with the coreceptors BAK1/SERK3 and SERK4 and relays the signaling through the activation of receptor-like cytosolic kinases (RLCKs) BIK1 and PBL1 (PubMed:33514716, PubMed:34535661). Also able to detect SCOOP-like proteins (SCOOPL) present in fungal Fusarium spp. and bacterial Comamonadaceae to elicit various immune responses, including growth inhibition, ROS production, calcium Ca(2+) influx, MAPK activation and MYB51 promoter activation in roots, thus being required for resistance to several root pathogens (PubMed:33514716, PubMed:34535661). Involved in the pollen tube perception of the female signal (PubMed:26863186). Required to trigger defense responses toward generalist herbivores such as Spodoptera littoralis, probably via the activation of jasmonate and indole glucosinolate biosynthesis (PubMed:35401621).<ref>PMID:26863186</ref> <ref>PMID:33514716</ref> <ref>PMID:34535661</ref> <ref>PMID:35401621</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Hu YX]]
[[Category: Wan LH]]
[[Category: Wu HM]]