View source for 8wg4


==mouse TMEM63b in DDM-CHS micelle with YN9303-24 Fab==
<StructureSection load='8wg4' size='340' side='right'caption='[[8wg4]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WG4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LBN:(2R)-3-(hexadecanoyloxy)-2-{[(9Z)-octadec-9-enoyl]oxy}propyl+2-(trimethylazaniumyl)ethyl+phosphate'>LBN</scene>, <scene name='pdbligand=P1L:S-PALMITOYL-L-CYSTEINE'>P1L</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wg4 OCA], [https://pdbe.org/8wg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wg4 RCSB], [https://www.ebi.ac.uk/pdbsum/8wg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wg4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CSCL2_MOUSE CSCL2_MOUSE] Mechanosensitive cation channel with low conductance and high activation threshold. Essential for the baby's first breath and respiration throughout life. Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:30382938, PubMed:37543036, PubMed:38127458). Osmosensitive cation channel preferentially activated by hypotonic stress. Acts as an osmosensor in cochlear outer hair cells (OHCs) where it mediates calcium influx and regulatory volume decrease response. Required for the maintenance of OHC morphology, OHC survival and normal hearing (PubMed:27045885, PubMed:31243992, PubMed:32375046, PubMed:37543036, PubMed:37945568).<ref>PMID:27045885</ref> <ref>PMID:30382938</ref> <ref>PMID:31243992</ref> <ref>PMID:32375046</ref> <ref>PMID:37543036</ref> <ref>PMID:37945568</ref> <ref>PMID:38127458</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aequorea victoria]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bamba T]]
[[Category: Hata K]]
[[Category: Iwata S]]
[[Category: Izumi Y]]
[[Category: Kuribayashi R]]
[[Category: Lee Y]]
[[Category: Liu K]]
[[Category: Miyata Y]]
[[Category: Nagata S]]
[[Category: Nishizawa T]]
[[Category: Nomura N]]
[[Category: Segawa K]]
[[Category: Sultan CS]]
[[Category: Takahashi K]]
[[Category: Takahashi M]]
[[Category: Uemura T]]