View source for 8wgm


==Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP==
<StructureSection load='8wgm' size='340' side='right'caption='[[8wgm]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_VS/1 Plasmodium falciparum VS/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WGM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wgm OCA], [https://pdbe.org/8wgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wgm RCSB], [https://www.ebi.ac.uk/pdbsum/8wgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wgm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A7UD81_PLAFA A7UD81_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum VS/1]]
[[Category: Arwon U]]
[[Category: Decharuangsilp S]]
[[Category: Kamchonwongpaisan S]]
[[Category: Saeyang T]]
[[Category: Vanichtanankul J]]
[[Category: Vitsupakorn D]]
[[Category: Yuthavong Y]]