View source for 8wla


==Cryo-EM structure of the beta-1,3-glucan synthase FKS1-Rho1 complex==
<StructureSection load='8wla' size='340' side='right'caption='[[8wla]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WLA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wla OCA], [https://pdbe.org/8wla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wla RCSB], [https://www.ebi.ac.uk/pdbsum/8wla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wla ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHO1_YEAST RHO1_YEAST] Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1,3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7.<ref>PMID:8195291</ref> <ref>PMID:7579704</ref> <ref>PMID:8846785</ref> <ref>PMID:8947028</ref> <ref>PMID:8621575</ref> <ref>PMID:8602514</ref> <ref>PMID:8602515</ref> <ref>PMID:11283608</ref> <ref>PMID:11447600</ref> <ref>PMID:12419188</ref> <ref>PMID:12207708</ref> <ref>PMID:12810699</ref> <ref>PMID:12928491</ref> <ref>PMID:15514049</ref> <ref>PMID:15596542</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Dai XL]]
[[Category: Deng D]]
[[Category: Li JL]]
[[Category: Liu JX]]
[[Category: Wang X]]
[[Category: Yan CY]]
[[Category: Zhu AQ]]