View source for 8wm0


==Crystal structure of TNIK-thiopeptide wTP3 complex==
<StructureSection load='8wm0' size='340' side='right'caption='[[8wm0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WM0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=WEH:(2~{S})-2,6-bis(azanyl)-6-oxidanylidene-hexanoic+acid'>WEH</scene>, <scene name='pdbligand=WET:(3~{S})-7-oxidanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic+acid'>WET</scene>, <scene name='pdbligand=WFZ:2-[2-(1-azanylethenyl)-1,3-thiazol-4-yl]-6-(4-methoxycarbonyl-1,3-thiazol-2-yl)pyridine-3-carboxylic+acid'>WFZ</scene>, <scene name='pdbligand=WGB:(2~{S})-2-(methylamino)-3-[4-[oxidanyl(oxidanylidene)azanuidyl]phenyl]propanoic+acid'>WGB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wm0 OCA], [https://pdbe.org/8wm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wm0 RCSB], [https://www.ebi.ac.uk/pdbsum/8wm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wm0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TNIK_HUMAN TNIK_HUMAN] Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.<ref>PMID:10521462</ref> <ref>PMID:15342639</ref> <ref>PMID:19061864</ref> <ref>PMID:19816403</ref> <ref>PMID:20159449</ref> <ref>PMID:21690388</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Goto Y]]
[[Category: Hamada K]]
[[Category: Kobayashi S]]
[[Category: Ogata K]]
[[Category: Sengoku T]]
[[Category: Suga H]]
[[Category: Vinogradov AA]]
[[Category: Zhang Y]]