View source for 8woq


==Cryo-EM structure of human SIDT1 protein with C1 symmetry at neutral pH==
<StructureSection load='8woq' size='340' side='right'caption='[[8woq]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8woq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WOQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8woq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8woq OCA], [https://pdbe.org/8woq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8woq RCSB], [https://www.ebi.ac.uk/pdbsum/8woq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8woq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIDT1_HUMAN SIDT1_HUMAN] In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.[UniProtKB:Q6AXF6]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liu W]]
[[Category: Ru H]]
[[Category: Tang M]]
[[Category: Wang J]]
[[Category: Wu S]]
[[Category: Zhang X]]