View source for 8wqu


==Fe-O nanocluster of form-IX in the 4-fold channel of Ureaplasma diversum ferritin==
<StructureSection load='8wqu' size='340' side='right'caption='[[8wqu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wqu]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Ureaplasma_diversum Ureaplasma diversum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WQU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wqu OCA], [https://pdbe.org/8wqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wqu RCSB], [https://www.ebi.ac.uk/pdbsum/8wqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wqu ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
All protein-directed syntheses of metal nanoclusters (NCs) and nanoparticles (NPs) have attracted considerable attention because protein scaffolds provide a unique metal coordination environment and can adjust the shape and morphology of NCs and NPs. However, the detailed formation mechanisms of NCs or NPs directed by protein templates remain unclear. In this study, by taking advantage of the ferritin nanocage as a biotemplate to monitor the growth of Fe-O NCs as a function of time, we synthesized a series of iron NCs with different sizes and shapes and subsequently solved their corresponding three-dimensional atomic-scale structures by X-ray protein crystallography and cryo-electron microscopy. The time-dependent structure analyses revealed the growth process of these Fe-O NCs with the 4-fold channel of ferritin as nucleation sites. To our knowledge, the newly biosynthesized Fe(35)O(23)Glu(12) represents the largest Fe-O NCs with a definite atomic structure. This study contributes to our understanding of the formation mechanism of iron NCs and provides an effective method for metal NC synthesis.

Growth Process of Fe-O Nanoclusters with Different Sizes Biosynthesized by Protein Nanocages.,Wang W, Xi H, Fu D, Ma D, Gong W, Zhao Y, Li X, Wu L, Guo Y, Zhao G, Wang H J Am Chem Soc. 2024 May 1;146(17):11657-11668. doi: 10.1021/jacs.3c13830. Epub , 2024 Apr 20. PMID:38641862<ref>PMID:38641862</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8wqu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ureaplasma diversum]]
[[Category: Gong WJ]]
[[Category: Ma DY]]
[[Category: Wang HF]]
[[Category: Wang WM]]
[[Category: Wu LJ]]